"At this stage it really makes no difference which driver is sitting in the car," team boss Christian Horner told Germany's Auto Motor und Sport.
Early testing of the all-new V6-powered cars has been fraught, and after getting less than a handful of laps under its belt on Tuesday, Red Bull packed up early on Wednesday with a "Renault energy store problem".
Other Renault-powered cars have reportedly also been affected, including the Caterham and the Toro Rosso.
Horner confirmed that sister team Toro Rosso suffered the same problem on Tuesday.
Mercedes-powered cars were much more prolific, including Jenson Button (McLaren), Nico Rosberg (Mercedes) and Sergio Perez (Force India), all with several dozen laps under their respective belts.
Vettel, on the other hand, managed just 11 laps with the RB10 over his two days, and now hands over to teammate Daniel Ricciardo.
"It was always likely that this (lack of running) was going to be the case," said car designer Adrian Newey, referring to the massive change in regulations since the end of the team's dominant display in 2013.
Newey is known for getting his new cars up and running at the eleventh hour, but even the famous Briton admitted he might have got to work earlier in the second half of last season, when Vettel was in the midst of his nine-race winning streak.
"With hindsight, perhaps in the second half we could have afforded to stop developing the car a little bit sooner," he is quoted by Britain's Sky, "but we weren't to know that at the time.
"So we kept pushing and had less time to work on this year's car."