"I've been taken out by a wasp!" the 34-year-old said on Twitter. "I was riding my bike yesterday and got stung between the eyes."
Button said the sting made him feel "rough, plus I look like an Avatar but obviously not the blue bit!"
Chat show host Graham Norton, sitting with actors Samuel L Jackson and Keira Knightley, phoned Button during the show and asked the F1 driver if he will be well enough to race in Austria this weekend.
"I hope so," Button answered. "That is the crazy thing. I drive around at 220 miles per hour and I get taken out by a wasp."
Pulp Fiction star Jackson, however, said he is not convinced.
"I want to see the face," he told Button. "I am not buying it."